Raffaele Medical is one of New York City's most distinguished longevity medicine practices — a Central Park South clinic that has spent 25 years pioneering the science of physiological age measurement and evidence-based healthy aging. Founded by Dr. Joseph M. Raffaele, a board-certified Internal Medicine physician and diplomat of the American Board of Age Management Medicine, the practice uses the proprietary PhysioAge Health Analytics platform to measure the true biological age of every major organ system — from the brain and arteries to the immune system and DNA itself. With over two decades of clinical research, including four published studies on telomerase activation and telomere biology, Dr. Raffaele has built one of the most scientifically rigorous and clinically proven longevity programs available anywhere in the country.

About the Physician

Dr. Joseph M. Raffaele, MD, earned his undergraduate degree in philosophy from Princeton University before completing his medical degree at Hahnemann University and his residency at The New York Hospital/Cornell University Medical Center. He went on to serve as a clinical assistant professor of medicine at Dartmouth Medical School before dedicating his career exclusively to longevity and age management medicine. He is board certified in Internal Medicine, a member of the American College of Physicians, and a diplomat of the American Board of Age Management Medicine. In 2007, Dr. Raffaele co-founded PhysioAge Systems — a biomarker data collection and reporting platform now used by longevity and integrative medicine practices around the world. Since 2009, he has conducted clinical research in telomere biology, publishing four studies on the effect of oral telomerase activation on the immune system, metabolism, and telomere length in aging adults.

Services Offered

• PhysioAge Next-Gen Diagnostics — A multi-omics assessment measuring the physiologic age of the brain, lungs, arteries, skin, and immune system, along with DNA epigenetic age and telomere length, delivering the most comprehensive picture of biological aging available.
• Women's Hormone Optimization — Customized, evidence-based hormone programs for women in perimenopause, menopause, and post-menopause, using bio-identical hormone therapy to restore energy, protect long-term health, and enhance quality of life.
• Men's Health & Hormone Recalibration — Multifaceted hormone optimization for men that goes beyond simple testosterone replacement to comprehensively recalibrate endocrine function, increase healthspan, and restore vitality and performance.
• Telomere Biology & Telomerase Activation — Clinical protocols informed by Dr. Raffaele's published research on oral telomerase activation, targeting telomere length as a measurable marker of cellular aging and immune system health.
• Personalized Longevity Planning — Individualized roadmaps integrating nutrition and fitness guidance, precision supplementation, hormone optimization, and pharmaceutical management tailored to each patient's unique biomarker profile.
• Epigenetic Age Assessment — DNA methylation-based testing revealing true biological age versus chronological age, used to track the impact of lifestyle and clinical interventions on the aging process.
• Immune System & Inflammatory Profiling — Advanced immune function assessment measuring the physiologic age of the immune system, identifying chronic low-grade inflammation and immune senescence driving accelerated aging.
• Ongoing Monitoring & Program Adjustment — Regular follow-up appointments, biomarker retesting, and program refinement ensuring each patient's plan evolves with their changing biology, supported by Jennifer Braun, MPH, PA-C.

What to Expect

Raffaele Medical is located at 30 Central Park South, Suite 8A, New York, NY 10019 — steps from Central Park in midtown Manhattan. Reach the practice at (212) 776-4956 or info@raffaelemedical.com. New patients can schedule a consultation at raffaelemedical.com. Dr. Raffaele and Jennifer Braun, PA-C, work collaboratively with each patient to design a longevity program tailored to their specific biomarker profile and health goals.